Palamur Biosciences has pool of scientists having extensive experience in drug discovery and regulatory services. Their in-depth knowledge of various disease conditions helps to design the clinically relevant disease models. Our service model is flexible and dovetailed to meet client’s requirements. Quick turn-around time, proper communication and transparency is the essence of our service model.

Quick overview of Pharma-Biotech services we can provide :

  • Toxicity Studies

    In vivo Toxicity studies

    • As per various OECD, Schedule Y and other regulatory guidelines
    • Reproductive Toxicity
    • Carcinogenicity
    • Acute-to-Chronic Toxicity
    • Reproductive Toxicity
    • Species: Mice, Rats, Rabbits, Dogs, Minipigs, Guinea Pigs

    Genotoxicity/ Mutagenicity

    • In vitro Micronucleus Test
    • In vivo Micronucleus Test
    • Cell gene Mutation Assay
    • Mouse Lymphoma Assay
    • As per various OECD, Schedule Y and other regulatory guidelines
    • Bacterial Reverse Mutation Test (Ames test)
    • In vitro Chromosomal Aberration Test
    • In vivo Chromosomal Aberration Test
    • Different cell lines for in vitro tests
    • Species for In vivo test: Mice, Rats
  • Efficacy Studies

    Therapeutic areas

    • Oncology
    • GIT activity
    • CNS activity
    • Surgically or Chemically-induced animal models
    • Pain and Inflammation
    • Metabolic Disorders
    • Cardiovascular disorders
    • Ophthalmic diseases


    • Mice, Rats, Guinea pigs, Rabbits, Dogs, Minipigs, Sheep, Goat
  • In vitro DMPK

    In vitro Permeability and P-gp Substrate Assessment

    • MDR1-MDCK cells
    • CACO2 cells


    • Cytochrome P450 Inhibition
    • Cytochrome P450 Induction
    • Metabolite identification
    • Microsomal Binding (Mice, Rat, Dog, Human)
    • Microsomal stability (Mice, Rat, Dog, Human)
    • Hepatocyte stability (Mice, Rat, Dog, Human)

    Plasma Protein Binding

    Plasma/Whole Blood Stability

    Blood-to-Plasma Ratio

  • In vivo Pharmacokinetics

    Pharmacokinetic Model

    • Absorption study
    • Excretion study
    • Tissue Distribution study
    • Blood Brain Barrier study

    Dosing and Sample Collection

    • Cannulated/ Non-cannulated animals
    • Single / Multiple dose
    • Different Routes of administration
    • Species: Mice, Rats, Guinea pigs, Rabbits, Dogs, Minipigs, Goat, Sheep
    • Specialized routes: Intranasal, Ophthalmic, Inhalation, Intratracheal, Depots
    • Ethically approved blood collection techniques
    • Various biological fluids and tissue sample collection

    Pharmacokinetic parameters evaluation using WinNonlin software

  • Bioanalysis

    Bioanalytical Method Development & Validation

    • Fit-for-research Method
    • Small and Large molecules
    • Partial/Complete method validation
    • Instruments: HPLC and LC-MS/MS

    Biological fluid analysis

    Tissue homogenization and analysis

  • Biological Formulations/ Biosimilars/ Vaccine candidates
    • Toxicity studies
    • Experience in handling wide range of Biological products
    • Analysis using ELISA, LC-MS/MS
    • Immunization studies
    • Pharmacopoeial Bioassays for Biosimilars
    • Clinically relevant Dosing Regimen
    • Immunization studies
    • In vivo Efficacy studies
  • Standalone Services
    • IND-enabling Studies
    • Histopathological services
    • Bioanalytical services
    • Archival Services
    • Pharmacokinetic parameters evaluation using WinNonlin software
    • Polyclonal/Monoclonal Antibody generation in various species
    • Hematology and Clinical Biochemistry Analysis
    • Providing various Tissues and Biological fluids including Plasma/Serum