In-vivo toxicology

Our range of services

In-vivo toxicology

Palamur Bio offers competitively priced GLP acute toxicology services. Our new streamlined protocols, redesigned in-life procedures and targeted reports allow us to offer scientific rigor with an operationally efficient service. Redesigning our approaches has translated directly into savings for our sponsors, without compromising objectives and quality.

The toxicology expertise at Palamur Bio encompasses a wide range of preclinical studies with rodents and non-rodents. The studies are spread over a spectrum of specialties, viz. single dose, MTD, 4, 13, 26, 52 weeks and beyond repeated exposure studies.

The expertise branches out into the evaluation of genotoxic, developmental and reproductive influences as well as Endocrine Disruption using various routes of administration. These studies are performed in compliance with global regulatory guidelines, viz. ICH, EMA, and related guidelines for the European, US FDA and global healthcare product registration efforts.

Quick overview of in-vivo services we can provide:

Pharma and Biotech Products Toxicity studies

Palamur undertakes testing of Pharma and Biopharma products using the following GLP toxicity studies in both rodents and non rodents (Beagle Dogs):

  • MTD studies
  • Dose Range finding studies
  • Phamacokinetic and Toxicokinetic studies
  • Palatability studies
  • Vaccine Efficacy studies
  • Acute Toxicity studies
  • Sub acute Toxicity studies
  • Sub chronic and chronic Toxicity studies
  • Reproductive Toxicity studies
  • In vitro Toxicity studies

Crop Care Products Toxicity studies

Palamur is well versed with all type of studies required for regulatory approval of crop care products. The following GLP toxicity studies are in place for using rodents and Beagle Dogs:

  • Acute Toxicity studies
  • Sub acute Toxicity studies
  • Sub chronic and chronic Toxicity studies
  • Carcinogenicity studies
  • Reproductive Toxicity studies
  • In vitro Toxicity studies
  • Metabolism studies in Live stock (Non-Radio label)

Eco-toxicology Studies

We currently perform the following Ecotoxicology studies for crop care chemicals:

Aquatic

  • Algae Growth Inhibition Test
  • Acute Immobilization Daphnia
  • Acute Fish Toxicity Test
  • Fish Prolonged Toxicity Test
  • Lemna Growth Inhibition Test

Terrestrial

  • Honey Bee Toxicity study (Oral / Contact)
  • Acute Earthworm Toxicity Test
  • Earthworm Reproduction Test
  • Acute Oral toxicity study in Birds
  • Acute Dietary toxicity study in Birds
  • Lemna Growth Inhibition Test

Inhalation Toxicology studies

We are specialists in conducting exposed inhalation studies for both pharma and crop care products. The following inhalation GLP toxicity studies are conducted:

  • Acute Inhalation Toxicity studies
  • Sub acute Inhalation Toxicity studies
  • Sub chronic and chronic Inhalation Toxicity studies
  • Customized Inhalation Toxicity studies

Mammalian Toxicology (Rodents & Non Rodents)

Single exposure / Maximum Tolerated Dose (MTD studies) studies using the following routes of exposure in rodents and non-rodents.

  • Oral, dermal, Respiratory, including evaluation of sensitization potential.

Repeat exposure studies in Rodents & Non-Rodents

  • Sub-acute (1, 2 and 4 week exposures)
  • Sub-chronic Toxicity (13 weeks)
  • Chronic Toxicity (26-52 weeks)
  • Carcinogenicity and Combined Carci (78 weeks in mice and 104 weeks in rats)

Developmental & Reproductive Toxicology

  • Fertility and early embryonic development
  • Embryo fetal development
  • Pre & Post natal Developmental Toxicity
  • One and multi generation reproductive Toxicity

These studies can be offered to cover the cohorts to interpret the effects on the natural biological influences on Neurotoxicity

  • Immune syetems
  • Neural systems
  • Respiratory systems
  • Renal systems
  • Hepatic processing
  • Peripheral systems including bone marrow
  • Circulatory systems (Toxicokinetics)
  • Specific biomarkers
  • Routine and specialized Hematology & Clinical chemistry
  • Hormonal assays
  • Conventional and targeted histopathology